In John Ford's sombre exploration mythologising of American heroes, he slowly reveals the character of Owen Thursday, who sees his new posting to the desolate Fort Apache as a chance to claim the military honour which he believes is rightfully his. Arrogant, obsessed with military form and ultimately self-destructive, Thursday attempts to destroy the Apache chief Cochise after luring him across the border from Mexico, against the advice of his subordinates.

When the government agency fails to deliver even the meager supplies due by treaty to the proud Cheyenne tribe in their barren desert reserve, the starving Indians have taken more abuse than it's worth and break it too by embarking on a 1,500 miles journey back to their ancestral hunting grounds. US Cavalry Capt. Thomas Archer is charged with their retrieval, but during the hunt grows to respect their noble courage, and decides to help them.

When Selby arrives as the new ranch owner, he is assumed to be just another cowboy attracted to Ann Hepburn so he takes a job as a dude cowhand. He learns cattle are being rustled and he suspects the boss Sam Hepburn. But Hepburn suspects the foreman Hyslip and when he catches him with the goods, Hyslip shoots him. Hyslip then blames the new dude, and sends his men out to kill him.

In this fable-morality subtitled "A Song of Two Humans", the "evil" temptress is a city woman who bewitches farmer Anses and tries to convince him to murder his neglected wife, Indre.